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sparsentan will lower the extent or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy connected with these substrates.In early studies, it's been recognised that modafinil is a well tolerated drug having a very low cha